Z557560
Aldrich
Chemical Process Research: The Art of Practical Organic Synthesis
| ISBN-10: | 0-84123824-3 |
| ISBN-13: | 978-0-84123824-4 |
Description
| General description | This book shows the diversity of structural problems and synthesis solution as well as the practical aspects and methodologies required for large-scale syntheses. The eleven chapters focus on chemical process research in the pharmaceutical industry. |
Properties
| publication info | A. Abdel-Magid and J. Ragan, Oxford University Press, 2003, 224 pp., hard cover |
Table Of Contents
| Table of Contents | Preface 1. Reflections on Process Research, 2. Synthesis of Cell Adhesion Inhibitors via Crystallization-Drivn Dynamic Transformations, 3. Synthetic, Structural, and Mechanistic Issues in the Development of a Subtype Selective GABA Partial Aginist Hypnotic Agent, 4. Process Research and Initial Scale-Up of ABT-839: A Farnesyltransferase Inhibitor, 5. Synthetic Approaches to the Retinoids, 6. Design of Experiments in Pharmaceutical Process Research and Development 7. Process Development for the MMP Inhibitor AG3433, 8. Dihydro-7-benzofurancarboxylix Acid: An Intermediate in the Synthesis of the Enterokinetic Agent R10852, 9. Process Research Leading to an Enantioselective Synthesis of a 5-Lipoxygenase Inhibitor for Asthma, 10. A Practical Synthesis of Tetrasubstituted Imidazole p38 MAP Kinase Inhibitors: A New Method for the Synthesis of alpha-Amidoketones, 11. Solution Phase Synthesis of the Pulmonary Surfactant KL4: A 21 Amino Acid Synthetic Protein Indexes Author Index Subject Index |
